Using well-known mechanisms that determine the epidemiology and stability of invasive antibiotic resistance plasmids in bacteria, we have developed simple and effective tools to remove them from the microflora. This gives us an uniquely positive solution to AMR and restores health to invaded bacterial ecosystems.
Antimicrobial resistance (AMR) curing and protection of the microbiota from AMR re-invasion (1-3). Microbiota protection (2-3) when needed, e.g. before hospital admission or overseas travel.
We construct plasmids to treat antibiotic resistance in bacteria. Our genetically modified (GM) therapeutic plasmids can be used to cure antibiotic resistance plasmids from bacteria in humans, animals and environmental ecosystems. Our GM-probiotic plasmids protect bacteria from acquisition of antibiotic resistance plasmids.
This procedure cures antibiotic resistance without killing of host bacterial populations. This preserves the microbiota and prevents ecological damage.
We expect to conduct first-in-human studies in late 2021.
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